Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis

• DOI: 10.1016/j.immuni.2024.11.004
• Publication Date: 2024-11-27T15:35:58Z
• Authors: Lucy MacDonald; Aziza Elmesmari; Domenico Somma; Jack Frew; Clara Di Mario; Roopa Madhu; Audrey Paoletti; Theodoros Simakou; Olympia M. Hardy; Barbara Tolusso; Denise Campobasso; Simone Perniola; Marco Gessi; Maria Rita Gigante; Luca Petricca; Dario Bruno; Lavinia Agra Coletto; Roberta Benvenuto; John D. Isaacs; Andrew Filby; David McDonald; Jasmine P.X. Sim; Nigel Jamieson; Kevin Wei; Maria Antonietta ...; Neal L. Millar; Simon Milling; Charles McSharry; Elisa Gremese; Karen Affleck; Kenneth F. Baker; Iain B. McInnes; Thomas D. Otto; Ilya Korsunsky; Stefano Alivernini; Mariola Kurowska-...
• Keywords: immune tolerance; synovial tissue; arthritis; spatial transcriptomics; disease remission; T cells; dendritic cells

Current rheumatoid arthritis (RA) treatments do not restore immune tolerance. Investigating dendritic cell (DC) populations in human synovial tissue (ST) may reveal pathways to reinstate tolerance RA. Using single-cell and spatial transcriptomics of ST biopsies, as well co-culture systems, we identified condition- niche-specific DC clusters with distinct functions. Healthy contained tolerogenic AXL