Cinnamaldehyde modulates LPS-induced systemic inflammatory response syndrome through TRPA1-dependent and independent mechanisms

• DOI: 10.1016/j.intimp.2016.02.012
• Publication Date: 2016-02-26T03:45:26Z
• Authors: Saulo J.F. Mendes; Fernanda I.A.B. S...; Domingos M.S. Per...; Thiago A.F. Ferro; Ione C.P. Pereira; Bruna L.R. Silva; Aruanã J.M.C.R. P...; Adriana Q.S. Mouc...; Valério Monteiro-...; Soraia K.P. Costa; José L.M. Nascimento; Marcos A.G. Grisotto; Robson da Costa; Elizabeth S. Fern...
• Keywords: Pharmacology; Lipopolysaccharides; 0303 health sciences; Cinnamomum zeylanicum; Macrophages; Immunology; Interleukin-1beta; Systemic Inflammatory Response Syndrome; Interleukin-10; 3. Good health; Disease Models, Animal; Mice; 03 medical and health sciences; Transient Receptor Potential Channels; Cell Movement; Pregnancy; Purines; Immunology and Allergy; Animals; Acetanilides; Female; Acrolein; TRPA1 Cation Channel

Cinnamaldehyde is a natural essential oil suggested to possess anti-bacterial and anti-inflammatory properties; activate transient receptor potential ankyrin 1 (TRPA1) channels expressed on neuronal non-neuronal cells. Here, we investigated the immunomodulatory effects of cinnamaldehyde in an vivo model systemic inflammatory response syndrome (SIRS) induced by lipopolysaccharide. Swiss mice received single oral treatment with h before LPS injection. To investigate whether are dependent TRPA1 activation, animals were treated subcutaneously selective antagonist HC-030031 5 min prior administration. Vehicle-treated used as controls. ameliorated SIRS severity LPS-injected animals. Diminished numbers circulating mononuclear cells increased peritoneal polymorphonuclear cell also observed. augmented number Ly6Chigh Ly6Clow monocyte/macrophage mice. Reduced levels nitric oxide, plasma TNFα IL-10 detected. Additionally, IL-1β same antagonism reversed changes leukocytes cinnamaldehyde-treated animals, whilst increasing reducing IL-1β. Overall, modulates through TRPA1-dependent independent mechanisms.