Predictive potential of STEAP family for survival, immune microenvironment and therapy response in glioma

• DOI: 10.1016/j.intimp.2021.108183
• Publication Date: 2021-10-12T11:06:13Z
• Authors: Zijun Zhao; Zairan Wang; Zihan Song; Yue Wu; Qianxu Jin; Zongmao Zhao
• Keywords: 0301 basic medicine; Gene Expression; Membrane Proteins; Antineoplastic Agents; Cell Cycle Proteins; Glioma; Real-Time Polymerase Chain Reaction; 3. Good health; 03 medical and health sciences; Antigens, Neoplasm; Cell Line, Tumor; Tumor Microenvironment; Humans; Immunotherapy; Oxidoreductases

Glioma is the most commonly diagnosed primary tumor of central nervous system. Previous studies found that the six-transmembrane epithelial antigen of prostate (STEAP) family can regulate the biological behaviors of several cancers. However, the role of STEAP family in glioma remains unclear. Here, we systematically evaluated the relationship between STEAP family and prognosis of glioma patients in multiple cohorts. The analysis showed that dysregulation of STEAP family may affect cancer-immunity cycle, immune infiltration and phenotypes resulting in an immunosuppressive microenvironment in glioma. To accurately predict the prognosis of glioma patients, gene-based risk models were established based on the expression of STEAP1, 2 and 3. Multivariate and univariate Cox analyses demonstrated that the risk models could independently predict the prognosis of glioma. Finally, chemotherapy and immune therapy responses for high- and low-risk patients were predicted. In conclusion, this study systematically analyzed the role of STEAP family in glioma and established a model for predicting therapy response in patients with glioma.