Cuproptosis-related gene PDHX and heat stress-related HSPD1 as potential key drivers associated with cell stemness, aberrant metabolism and immunosuppression in esophageal carcinoma

• DOI: 10.1016/j.intimp.2023.109942
• Publication Date: 2023-03-06T17:40:23Z
• Authors: Runmin Jiang; Ying Sun; Yan Li; Xuefei Tang; Bengang Hui; Shouzheng Ma; Jiao Zhang; Chun Sun; Jiyi Tan; Boyan Zhou; Jie Lei; Tao Jiang
• Keywords: Immunosuppression Therapy; Mitochondrial Proteins; Esophageal Neoplasms; Carcinoma; Humans; Pyruvate Dehydrogenase Complex; Apoptosis; Chaperonin 60; Algorithms; Copper; 3. Good health

Heat stress is fundamental to esophageal carcinoma (ESCA) oncogenesis and progression. damages epithelial structure, causing aberrant 'cell death-repair' patterns of esophagus cells thereby driving tumor occurrence However, due the distinctive functions crosstalk regulatory cell death (RCD) patterns, specific deaths in ESCA malignancy are still unclear.We analyzed key genes involved heat progression by using The Cancer Genome Atlas-ESCA database. least absolute shrinkage selection operator (LASSO) algorithm was used filter genes. one-class logistic regression (OCLR) quanTIseq methods were evaluate stemness immune infiltration samples. Cell counting kit-8 (CCK8) wound healing assays performed assess proliferation migration cells.We found that cuproptosis may be a potential risk factor stress-related ESCA. Two interrelated genes, HSPD1 PDHX, associated with played role survival, proliferation, migration, metabolism immunosuppression.We promoted related stress, offering new therapeutic opportunity treat this malignant disorder.