Attenuated memory impairment and neuroinflammation in Alzheimer’s disease by aucubin via the inhibition of ERK-FOS axis

• DOI: 10.1016/j.intimp.2023.111312
• Publication Date: 2023-12-04T02:29:56Z
• Authors: Cuicui Wang; Xiaolin Cui; Zhenfang Dong; Yingchao Liu; Pengcheng Xia; Xueying Wang; Zhi Zhang; Shuyi Yu; Shuang Wu; Huan Liu; Shuai Zong; Zhiming Lu

Alzheimer's disease (AD) is a degenerative illness accompanied by cognitive and memory loss. In addition to the widely accepted, convincing amyloid cascade hypothesis, activation of glial cells neuroinflammation, especially microglia-mediated has an essential role in development progression AD. Therefore, anti-inflammatory treatment becoming promising therapeutic strategy. Aucubin (Au) natural product derived from many plants with antioxidant activities. Up now, no research been conducted investigate effects Au its neuroprotective quality on AD potential molecular mechanisms medical roles. our study, results network pharmacology revealed effect The studies vivo showed that improved behaviors, counteracted deficits, ameliorated AD-like pathological features mouse brain, e.g., deposition Aβ plaques, neuronal damage, inflammatory responses induced cell overactivation, APP/PS1 mice. transcriptome sequencing further confirmed symptoms could be reversed inhibiting ERK/FOS axis alleviate response. vitro experiments suppressed BV2 activation, inhibited phosphorylation ERK1/2 expression c-FOS, reduced LPS-induced mediator production primary astrocytes. Our study suggested exerted responses, which