The relationship and clinical significance of serum cytokine expression level and skin pruritus in patients with Hodgkin lymphoma and angioimmunoblastic T-cell lymphoma

• DOI: 10.1016/j.intimp.2024.111777
• Publication Date: 2024-03-14T17:07:58Z
• Authors: Xin Wen; Hui Yu; Lei Zhang; Ling Li; Xinhua Wang; Xiaorui Fu; Zhenchang Sun; Xudong Zhang; Linan Zhu; Xiaolong Wu; Jiaqin Yan; Cunzhen Shi; Mengjuan Zhang; Mingzhi Zhang; Xin Li
• Keywords: Angioimmunoblastic T-cell lymphoma; Proinflammatory cytokine; Aggressive lymphoma

Pruritus of lymphoma is commonly associated with both Hodgkin (HL) and angioimmunoblastic T cell (AITL) critically affects the life quality patient. Recent evidence suggests that pruritogenic cytokines seem to play a significant role in genesis chronic. This study aims investigate itching patients provide basis for potential therapeutic targets. Serum samples were collected from 60 patients, including 47 13 T-cell (AITL), serving as observation group (lymphoma group, LP n = 60). Additionally, serum 8 healthy donors (HD 8) comparison. Within stratified into those pruritus (LWP 30) without (LWOP based on presence skin symptoms. Elevated levels multiple significantly observed comparison HD (p < 0.01). Patients LWP exhibited higher IL-31 0.001), IL-1β (P 0.039), IL-1α 0.037) compared LWOP group. Notably, advanced AITL (stage IV) than early I-Ⅲ, P 0.05). In subgroup analysis, MIG CTACK HL whereas PDGF-BB lower IL-31, IL-1β, are linked lymphoma-associated pruritus. Differences cytokine profiles between subgroups also highlighted. These findings offer valuable insights clinical intervention managing lymphoma-related