Unveiling YWHAH: A potential therapeutic target for overcoming CD8+ T cell exhaustion in colorectal cancer

• DOI: 10.1016/j.intimp.2024.112317
• Publication Date: 2024-05-25T08:56:30Z
• Authors: Qiang Li; Zhao Yuan; Yuan Wang; Peng Zhai; Jian Wang; Chen Zhang; Ziqi Shao; Chungen Xing
• Keywords: Gene Expression Regulation, Neoplastic; 14-3-3 Proteins; Cell Line, Tumor; Humans; Cytidine; CD8-Positive T-Lymphocytes; Colorectal Neoplasms; Immune Checkpoint Inhibitors; T-Cell Exhaustion

Colorectal cancer (CRC) is a significant global health challenge, with increasing rates of incidence and mortality. Despite advancements in immunotherapy, resistance, particularly due to T cell exhaustion, remains major hurdle. This study explores the role YWHAH, mediated by N4-acetylcytidine (ac4C) modification, CRC progression its impact on CD8