Tet2 modulates M2 macrophage polarization via mRNA 5-methylcytosine in allergic rhinitis

• DOI: 10.1016/j.intimp.2024.113495
• Publication Date: 2024-11-01T08:28:41Z
• Authors: Wenjun Fan; Peiqiang Liu; Lu Tan; Hao Lv; Huiqin Zhou; Zezhang Tao; Yu Xu
• Keywords: Macrophage polarization; 5-Methylcytosine

Allergic rhinitis (AR) represents a hallmark of obvious hypersensitivity with an imbalance immune responses, including abnormal macrophage activity in local tissues. It has been reported that alternatively activated macrophages (M2) may contribute to allergic pathogenesis. Ten-eleven translocation (Tet) enzymes can oxidize 5-methylcytosine (m5C) mRNA, implying the epigenetic regulation post-transcriptional RNA modification. Our previous study suggested decreased Tet2 impairs function regulatory T cells, failing exert protective role AR. However, mechanism polarization little discussed. In this paper, we investigate under inflammation.