The Ancestral Environment Shapes Antiviral CD8+ T cell Responses across Generations

• DOI: 10.1016/j.isci.2019.09.014
• Publication Date: 2019-09-14T14:47:51Z
• Authors: Christina M. Post; Lisbeth A. Boule; Catherine G. Burke; Colleen T. O'Dell; Bethany Winans; B. Paige Lawrence
• Keywords: Transgenerational epigenetics

Recent studies have linked health fates of children to environmental exposures their great grandparents. However, few considered whether ancestral influence immune function across generations. Here, we report transgenerational inheritance altered T cell responses resulting from maternal (F0) exposure the aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Since F0 TCDD has been transmission reproductive problems, asked also caused changes in function. effects on CD8