The Mechanism of β2m Molecule-Induced Changes in the Peptide Presentation Profile in a Bony Fish

• DOI: 10.1016/j.isci.2020.101119
• Publication Date: 2020-04-30T17:22:09Z
• Authors: Zibin Li; Nianzhi Zhang; Lizhen Ma; Lijie Zhang; Geng Meng; Chun Xia
• Keywords: CTL*

Contemporary antigen presentation knowledge is based on the existence of a single β2m locus, and classical MHC class I forms complex with peptide (i.e., pMHC-I) to trigger CTL immunity. However, two loci have been found in diploid bony fish; function molecules unclear. Here, we determined variant profiles originating from different products binding same MHC-I molecule further solved crystal structures pMHC-I pCtid-UAA-β2m-2 pCtid-UAA-β2m-1-II). Of note, pCtid-UAA-β2m-2, unique hydrogen bond network formed bottom peptide-binding groove (PBG) led α2-helix drift, ultimately leading structural changes PBG. The mechanism change by illustrated. results are also great significance for antivirus antitumor functions cold-blooded vertebrates even humans.