A NKp80-Based Identification Strategy Reveals that CD56neg NK Cells Are Not Completely Dysfunctional in Health and Disease

• DOI: 10.1016/j.isci.2020.101298
• Publication Date: 2020-06-20T13:34:18Z
• Authors: Ane Orrantia; Iñigo Terrén; Alicia Izquierdo-...; Juncal A. Alonso-...; Victor Sandá; Joana Vitallé; Santiago Moreno; María Tasias; Alasne Uranga; Carmen González; Juan J. Mateos; Juan C. García-Ruiz; Olatz Zenarruzabe...; Francisco Borrego
• Keywords: Dysfunctional family; Identification

Natural killer (NK) cells are usually identified by the absence of other lineage markers, due to lack cell-surface-specific receptors. CD56neg NK cells, classically as CD56negCD16+, very scarce in peripheral blood healthy people but they expand some pathological conditions. However, studies on had revealed different results regarding phenotype and functionality. This could be to, among others, unstable expression CD16, which hinders cells' proper identification. Hence, we aim determine an alternative surface marker CD16 better identify cells. We have found that NKp80 is superior CD16. Furthermore, differences between functionality CD56negNKp80+ suggesting effector functions not diminished previously thought. proposed a noteworthy accurately re-characterize human