Intergenerational effect of short-term spaceflight in mice

• DOI: 10.1016/j.isci.2021.102773
• Publication Date: 2021-06-25T16:39:16Z
• Authors: Keisuke Yoshida; Shin-ichiro Fujita; Ayako Isotani; Takashi Kudo; Satoru Takahashi; Masahito Ikawa; Dai Shiba; Masaki Shirakawa; Masafumi Muratani; Shunsuke Ishii
• Keywords: Spaceflight; Transcription

As space travel becomes more accessible, it is important to understand the effects of spaceflight including microgravity, cosmic radiation, and psychological stress. However, effect on offspring has not been well studied in mammals. Here we investigated 35 days male germ cells. Male mice that had experienced exhibit alterations binding transcription factor ATF7, a regulator heterochromatin formation, promoter regions testis, as altered small RNA expression spermatozoa. Offspring space-traveling males elevated hepatic genes related DNA replication. These results indicate intergenerational effect.