Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells

• DOI: 10.1016/j.isci.2021.102837
• Publication Date: 2021-07-10T23:23:23Z
• Authors: Xianjin Kan; Yuncong Yin; Cuiping Song; Lei Tan; Xusheng Qiu; Ying Liao; Weiwei Liu; Songshu Meng; Yingjie Sun; Chan Ding
• Keywords: Newcastle Disease

A number of new cell death processes have been discovered in recent years, including ferroptosis, which is characterized by the accumulation lipid peroxidation products derived from iron metabolism. The evidence suggests that ferroptosis has a tumor-suppressor function. However, mechanism mediates response tumor cells to oncolytic viruses remains poorly understood. Newcastle disease virus (NDV) can selectively replicate cells. We show NDV-induced acts through p53-SLC7A11-GPX4 pathway. Meanwhile, levels intracellular reactive oxygen species and peroxides increased Ferritinophagy was induced NDV promotion release ferrous an enhanced Fenton reaction. Collectively, these observations demonstrated kill ferroptosis. Our study provides novel insights into mechanisms highlights critical role treating therapy-resistant cancers.