Immunoglobulin G glycome composition in transition from premenopause to postmenopause

• DOI: 10.1016/j.isci.2022.103897
• Publication Date: 2022-02-10T17:13:15Z
• Authors: Helena Deriš; Domagoj Kifer; Ana Cindrić; Tea Petrović; Ana Cvetko; Irena Trbojević-A...; Ivana Kolčić; Ozren Polašek; Louise Newson; Tim Spector; Cristina Menni; Gordan Lauc
• Keywords: Glycome; Proinflammatory cytokine

Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of molecular mechanisms behind increased phenotype in perimenopause. Using ultra-high-performance liquid chromatography, we analyzed 5,080 samples from 1940 pre-, peri-, postmenopausal women. Statistically significant decrease galactosylation sialylation was observed Furthermore, during transition pre- to period, rate increase agalactosylated structures (0.051/yr; 95%CI = 0.043–0.059, p < 0.001) digalactosylated (−0.043/yr; −0.050 −0.037, monosialylated glycans (−0.029/yr; −0.034 −0.024, were significantly higher than either or periods. The conversion resulting ability suppress low-grade chronic inflammation may an important mechanism mediating health risk perimenopause postmenopause.