CD6 deficiency impairs early immune response to bacterial sepsis

• DOI: 10.1016/j.isci.2022.105078
• Publication Date: 2022-09-05T07:23:24Z
• Authors: Cristina Català; María Velasco-de ...; Alejandra Leyton-...; Sergi Casadó-Llom...; Manuel Sáez Moya; Rebeca Gutiérrez-...; Joaquín García-Luna; Marta Consuegra-F...; Marcos Isamat; Fernando Aranda; Mario Martínez-Fl...; Pablo Engel; Gustavo Mourglia-...; Francisco Lozano
• Keywords: Adoptive Cell Transfer

CD6 is a lymphocyte-specific scavenger receptor expressed on adaptive (T) and innate (B1a, NK) immune cells, which involved in both fine-tuning of lymphocyte activation/differentiation recognition bacterial-associated molecular patterns (i.e., lipopolysaccharide). However, evidence CD6's role the physiological response to bacterial infection was missing. Our results show that induction monobacterial polymicrobial sepsis Cd6-/- mice lower survival rates increased loads pro-inflammatory cytokine levels. Steady state analyses decreased levels natural polyreactive antibodies, concomitant with cell counts spleen B1a marginal zone B cells. Adoptive transfer wild-type cells mouse serum, as well monoclonal antibody improve post-sepsis. These findings support nonredundant for early against infection, through homeostatic expansion functionality innate-related