CEACAM1 is a direct SOX10 target and inhibits melanoma immune infiltration and stemness

• DOI: 10.1016/j.isci.2022.105524
• Publication Date: 2022-11-07T18:03:28Z
• Authors: John Abou-Hamad; Jonathan J. Hodgins; Christiano T. de ...; Brennan Garland; Cédrik Labrèche; Marie Marotel; Cameron Gibson; Samuel Delisle; Julia Pascoal; Rebecca C. Auer; Michele Ardolino; Luc A. Sabourin
• Keywords: SOX10

SOX10 is a key regulator of melanoma progression and promotes melanocytic/differentiated state. Here we identified cell lines lacking expression which retain their in vivo growth capabilities. More importantly, find that can regulate T-cell infiltration while also decreasing common cancer stem (CSC) properties. We show regulates CEACAM1, surface protein with immunomodulatory directly binds to distal CEACAM1 promoter region approximately 3-4kbps from the transcriptional start site. Furthermore, SOX10-CEACAM1 axis suppress CD8+ as well reduce CSC pool within tumors, leading reduced tumor growth. Overall, these results identify direct uncover both pro- anti-tumorigenic roles for melanoma.