Enteral liquid ventilation oxygenates a hypoxic pig model

• DOI: 10.1016/j.isci.2023.106142
• Publication Date: 2023-02-13T17:13:11Z
• Authors: Tasuku Fujii; Yosuke Yoneyama; Akiko Kinebuchi; Naoki Ozeki; Sho Maeda; Norikazu Saiki; Toyofumi Fengshi ...; Hiroshi Date; Kimitoshi Nishiwaki; Takanori Takebe
• Keywords: Oxygenate; Enteral administration; Hypoxia

The potential of extrapulmonary ventilation pathways remains largely unexplored. Here, we assessed the enteral approach in hypoxic porcine models under controlled mechanical ventilation. 20 mL/kg oxygenated perfluorodecalin (O2-PFD) was intra-anally delivered by a rectal tube. We simultaneously monitored arterial and pulmonary blood gases every 2 min up to 30 determine gut-mediated systemic venous oxygenation kinetics. Intrarectal O2-PFD administration significantly increased partial pressure oxygen from 54.5 ± 6.4 61.1 6.2 mmHg (mean SD) reduced carbon dioxide 38.0 5.6 34.4 5.9 mmHg. Early transfer dynamics inversely correlate with baseline status. SvO2 dynamic monitoring data indicated that likely originated outflow broad segment large intestine including inferior mesenteric vein route. Enteral pathway offers an effective means for oxygenation, thus warranting further clinical development.