Mitochondrial Bcl-xL promotes brain synaptogenesis by controlling non-lethal caspase activation

• DOI: 10.1016/j.isci.2023.106674
• Publication Date: 2023-04-14T09:10:00Z
• Authors: Trang Thi Minh Ng...; Rudy Gadet; Marine Lanfranchi; Romane A. Lahaye; Sozerko Yandiev; Olivier Lohez; Ivan Mikaelian; Lea Jabbour; Ruth Rimokh; Julien Courchet; Frédéric Saudou; Nikolay Popgeorgiev; Germain Gillet
• Keywords: Bcl-xL; Synaptogenesis; Caspase-9

Non-lethal caspase activation (NLCA) has been linked to neurodevelopmental processes. However, how neurons control NLCA remains elusive. Here, we focused on Bcl-xL, a Bcl-2 homolog regulating through the mitochondria. We generated mouse model, referred as ER-xL, in which Bcl-xL is absent mitochondria, yet present endoplasmic reticulum. Unlike