Timing and implications for immune response to vaccine in SARS-CoV-2 breakthrough infections

• DOI: 10.1016/j.isci.2023.106716
• Publication Date: 2023-04-23T01:53:53Z
• Authors: Stefania Arsuffi; Emanuele Sansone; Emanuele Focà; Samuele Storti; Teresa Diaferia; Carlo Bonfanti; Luigina Terlenghi; Arnaldo Caruso; Emma Sala; Francesco Castelli; Giuseppe De Palma; Eugenia Quiros-Ro...
• Keywords: Antibody response; Antibody titer

COVID-19 vaccines elicit a strong anti-S antibodies response. We aim to describe antibody titers in peri-vaccination SARS-CoV-2 infections. This is retrospective longitudinal single-cohort study. Serological tests were performed at the time of first vaccine dose (T0) and 60 (T1), 120 (T2), 240 (T3) days after. The study included 4,682 subjects. Group A had infection without an Ig B C seroconverted for anti-N between T0 T1 T2, respectively. D was persistently negative. showed initial sub-optimal response, reaching highest titer T3. Those who received second after higher compared those it 21 dose. immune response depends on number timing doses, highlighting need more personalized approach vaccination.