Inhibiting neuronal AC1 for treating anxiety and headache in the animal model of migraine

• DOI: 10.1016/j.isci.2023.106790
• Publication Date: 2023-04-28T17:02:30Z
• Authors: Ren-Hao Liu; Mingjie Zhang; Man Xue; Tao Wang; Jing-Shan Lu; Xu-Hui Li; Yu-Xin Chen; Kexin Fan; Wantong Shi; Si-Bo Zhou; Qi-Yu Chen; Li Kang; Qian Song; Shengyuan Yu; Min Zhuo
• Keywords: Animal model

Migraines are a common medical condition. From basic science point of view, the central mechanism for migraine and headache is largely unknown. In present study, we demonstrate that cortical excitatory transmission significantly enhanced in anterior cingulate cortex (ACC)-a brain region which critical pain perception. Biochemical studies found phosphorylation levels both NMDA receptor GluN2B AMPA GluA1 were ACC rats. Both presynaptic release glutamate postsynaptic responses receptors enhanced. Synaptic long-term potentiation (LTP) was occluded. Furthermore, behavioral anxiety nociceptive increased, reversed by application AC1 inhibitor NB001 within ACC. Our results provide strong evidence LTPs contribute to migraine-related anxiety. Drugs inhibit excitation such as may serve potential medicines treating future.