Genetically proxied impaired GIPR signaling and risk of 6 cancers

• DOI: 10.1016/j.isci.2023.106848
• Publication Date: 2023-05-10T00:53:35Z
• Authors: Miranda Rogers; Dipender Gill; Emma Ahlqvist; Tim Robinson; Daniela Mariosa; Mattias Johansson; Ricardo Cortez Ca...; Laure Dossus; Marc J. Gunter; Victor Moreno; George Davey Smith; Richard M. Martin; James Yarmolinsky
• Keywords: 0301 basic medicine; name=ICEP; Science; Q; Medical genetics; 610; Health sciences; 600; Article; 3. Good health; /dk/atira/pure/core/keywords/icep; Genètica mèdica; 03 medical and health sciences; /dk/atira/pure/core/keywords/population_health_SRI; Genetics; name=Bristol Population Health Science Institute; Càncer; Cancer

Preclinical and genetic studies suggest that impaired glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling worsens glycemic control. The relationship between GIPR the risk of cancers influenced by glucose homeostasis is unclear. We examined association a variant in