Lemon-derived nanovesicles achieve antioxidant and anti-inflammatory effects activating the AhR/Nrf2 signaling pathway

• DOI: 10.1016/j.isci.2023.107041
• Publication Date: 2023-06-08T00:24:59Z
• Authors: Ornella Urzì; Marco Cafora; Nima Rabienezhad ...; Vincenza Tinnirello; Roberta Gasparro; Samuele Raccosta; Mauro Manno; Anna Maria Corsale; Alice Conigliaro; Anna Pistocchi; Stefania Raimondo; Riccardo Alessandro
• Keywords: Inflammation; Nrf2 signaling pathway; Cell biology; Molecular biology; Science; Immunology; Q; OXIDATIVE STRESS; TRANSFERRIN RECEPTOR; INFLAMMATION; NRF2; FIBROBLASTS; MICRORNAS; MECHANISM; GROWTH; CELLS; MODEL; Citrus Lemmon; Article; Plant vesicles

In the last years, extracellular vesicles (EVs) from different plant matrices have been isolated and gained interest of scientific community for their intriguing biological properties. this study, we characterized nanovesicles lemon juice (LNVs) evaluated antioxidant effects. We tested LNV activity using human dermal fibroblasts that were pre-treated with LNVs 24 h then stimulated hydrogen peroxide (H