GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells

• DOI: 10.1016/j.isci.2023.107341
• Publication Date: 2023-07-16T12:04:18Z
• Authors: Fei Guan; Xi Luo; Ju Liu; Yanmei Huang; Qi Liu; Jiang Chang; Guofeng Fang; Danqing Kang; Heng Gu; Li Luo; Lu Yang; Zhaoyu Lin; Xiang Gao; Chaohong Liu; Jiahui Lei
• Keywords: breakpoint cluster region; Cell Signaling

Metabolism plays a crucial role in B cell differentiation and function. GSDMA3 is related to mitochondrial metabolism involved immune responses. Here, we used Gsdma3 KO mice examine the effect of on cells. The results demonstrated that deficiency reprogrammed metabolism, evidenced by upregulating PI3K-Akt-mTOR signaling, along with elevated ROS reproduction reduced maximal oxygen consumption rate mitochondria. Moreover, BCR signaling cells was impaired. associated decreased clustering, caused inhibited activation WASP. However, had no effects development functions humoral immunity, which might be compensation upregulated GSDMA2 expression fine balance between PI3K signals interaction. Our observations reveal previously unknown influence under physiological immunized states.