Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes

• DOI: 10.1016/j.isci.2023.107548
• Publication Date: 2023-08-07T15:32:27Z
• Authors: Prem Swaroop Yadav; Garyfallia Papaio...; Margaret M. Kobelski; Marie B. Demay
• Keywords: Cell biology; Molecular biology; Science; Q; Article

Low circulating phosphate (Pi) leads to rickets, characterized by expansion of the hypertrophic chondrocytes (HCs) in growth plate due impaired HC apoptosis. Studies HCs demonstrate that Pi activates Raf/MEK/ERK1/2 and mitochondrial apoptotic pathways. To determine how these pathways, a small-molecule screen was undertaken identify inhibitors Pi-induced ERK1/2 phosphorylation HCs. Vascular endothelial factor receptor 2 (VEGFR2) identified as target.