LncRNA TYMSOS facilitates breast cancer metastasis and immune escape through downregulating ULBP3

• DOI: 10.1016/j.isci.2023.107556
• Publication Date: 2023-08-07T15:43:58Z
• Authors: Ke-Jing Zhang; Xiao-Lang Tan; Lei Guo
• Keywords: Biological sciences; Molecular biology; Science; Immunology; Q; Article; 3. Good health; Cancer

The focus of the study is to examine function TYMSOS in immune escape breast cancer, which most frequently diagnosed malignancy among women globally. Our demonstrated that upregulated was associated with unfavorable prognosis and cancer. promoted malignant phenotypes cancer cells, reduced cytotoxicity NK92 cells on these cells. CBX3 a downstream effector TYMSOS-induced Mechanistic studies showed facilitated CBX3-mediated transcriptional repression ULBP3, it also SYVN1-mediated ubiquitin-proteasomal degradation ULBP3. cell growth, metastasis, via CBX3/ULBP3 or SYVN1/ULBP3 axis. vivo further silencing repressed tumor growth boosted NK cytotoxicity. In sum, metastasis