Immunogenicity of COVID-19 vaccines and their effect on HIV reservoir in older people with HIV

• DOI: 10.1016/j.isci.2023.107915
• Publication Date: 2023-09-14T03:34:31Z
• Authors: Vitaliy A. Matveev; Erik Z. Mihelic; Erika Benko; Patrick Budylowski; Sebastian Grocott; Terry Lee; Chapin S. Korosec; Karen Colwill; Henry Stephenson; Ryan Law; Lesley A. Ward; Salma Sheikh-Mohamed; Geneviève Mailhot; Melanie Delgado-B...; Adrian Pasculescu; Jenny H. Wang; Freda Qi; Tulunay Tursun; Lela Kardava; Serena Chau; Philip Samaan; Annam Imran; Dennis C. Copertino; Gary Chao; Yoojin Choi; Robert J. Reinhard; Rupert Kaul; Jane M. Heffernan; R. Brad Jones; Tae-Wook Chun; Susan Moir; Joel Singer; Jennifer Gommerman; Anne-Claude Gingras; Colin Kovacs; Mario Ostrowski
• Keywords: Viremia

Older individuals and people with HIV (PWH) were prioritized for COVID-19 vaccination, yet comprehensive studies of the immunogenicity these vaccines their effects on reservoirs are not available. Our study 68 PWH 23 HIV-negative participants aged 55 older post-three vaccine doses showed equally strong anti-spike IgG responses in serum saliva through week 48 from baseline, while salivary IgA low. had diminished live-virus neutralization after two doses, which 'rescued' post-booster. Spike-specific T cell immunity was enhanced normal CD4