AIM2 promotes TH17 cells differentiation by regulating RORγt transcription activity

• DOI: 10.1016/j.isci.2023.108134
• Publication Date: 2023-10-05T01:17:19Z
• Authors: Jefferson Antônio...; Luísa Menezes; Eloisa Martins; Tamara Silva Rodr...; Lucas Tavares; Anna Ebering; Carsten Schelmbauer; Guilherme C. Mart...; Valeriya Zinina; Artemiy Golden; Natalia Soshnikova; Dario S. Zamboni; Fernando Q. Cunha; Magdalena Huber; João Santana Silva; Ari Waisman; Daniela Carlos; Niels Olsen Sarai...
• Keywords: AIM2

AIM2 is an interferon-inducible HIN-200 protein family member and well-documented for its roles in innate immune responses as a DNA sensor. Recent studies have highlighted AIM2's function on regulatory T cells (Treg) follicular (Tfh). However, involvement Th17 cell differentiation remains unclear. This study reveals that promotes differentiation. deficiency decreases IL-17A production downregulates key associated proteins (RORγt, IL-1R1, IL-23R). located the nucleus of cells, where it interacts with RORγt, enhancing binding to Il17a promoter. The absence hinders naive CD4 from differentiating into functional inducing colitis Rag1-/- mice. uncovers role regulator transcriptional programming, highlighting potential therapeutic target cell-mediated inflammatory diseases.