Nuclear pore complex proteins are involved in centromere distribution

• DOI: 10.1016/j.isci.2024.108855
• Publication Date: 2024-01-11T09:46:41Z
• Authors: Nanami Ito; Takuya Sakamoto; Yuka Oko; Hikaru Sato; Shigeru Hanamata; Yuki Sakamoto; Sachihiro Matsunaga
• Keywords: Nucleoporin; Nuclear pore; Nucleoplasm

The subnuclear distribution of centromeres is cooperatively regulated by condensin II and the linker nucleoskeleton cytoskeleton (LINC) complex. However, other nuclear membrane structures proteins are probably involved in centromere dynamics distribution. Here, we focused on pore complex (NPC), which known to regulate gene expression, transcription memory, chromatin structure addition transport between cytoplasm nucleoplasm. We report here that some nucleoporins (Nups), including Nup85, Nup133, CG1, Nup93b, NUA, scattering