OVOL2 induces autophagy-mediated epithelial-mesenchymal transition by the ERK1/2 MAPK signaling in lung adenocarcinoma

• DOI: 10.1016/j.isci.2024.108873
• Publication Date: 2024-01-11T17:32:24Z
• Authors: Yali Wang; Lin Shi; Yuchao He; Wenchen Gong; Yanyan Cui; Ran Zuo; Yu Wang; Yi Luo; Liwei Chen; Zhiyong Liu; Peng Chen; Hua Guo
• Keywords: 0303 health sciences; 03 medical and health sciences; Molecular biology; Science; Q; Pathophysiology; Article; Cancer

Lung adenocarcinoma (LUAD) is one of the leading causes cancer-related death worldwide. Epithelial-mesenchymal transition (EMT) plays an important role in malignant tumor progression. Recently, accumulating evidence has shown that autophagy involved regulation EMT-induced migration. Therefore, exploration targets to inhibit EMT by targeting important. In this study, we found OVO-like zinc finger 2 (OVOL2) may be a key target for regulating autophagy-induced EMT. Firstly, OVOL2 expression was dramatically downregulated LUAD. Low indicator poor prognosis