Recognition of yeast β-glucan particles triggers immunometabolic signaling required for trained immunity

• DOI: 10.1016/j.isci.2024.109030
• Publication Date: 2024-01-26T19:38:56Z
• Authors: Cian J.H. Horneck...; Anna E. Ledwith; Mimmi L.E. Lundahl; Hugo Charles-Mess...; Emer E. Hackett; Simon D. O’Shaugh...; Jonah Clegg; Hannah Prendeville; John P. McGrath; Aaron M. Walsh; Sarah Case; Hollie Austen Byrne; Parth Gautam; Elaine Dempsey; Sinead C. Corr; Frederick J. Sheedy
• Keywords: Beta-glucan; Plant Immunity; Monocyte

Fungal β-glucans are major drivers of trained immunity which increases long-term protection against secondary infections. Heterogeneity in β-glucan source, structure, and solubility alters interaction with the phagocytic receptor Dectin-1 could impact strategies to improve humans. Using a panel diverse β-glucans, we describe ability specific yeast-derived whole-glucan particle (WGP) reprogram metabolism thereby drive human monocyte-derived macrophages