Inhibitors to degraders: Changing paradigm in drug discovery

• DOI: 10.1016/j.isci.2024.109574
• Publication Date: 2024-03-26T17:28:41Z
• Authors: V. Haridas; Souvik Dutta; Akshay Munjal; Shailja Singh
• Keywords: Chimera (genetics); Paradigm shift; Protein Degradation

The chemical understanding of biological processes provides not only a deeper insight but also solution to abnormal functioning. Protein degradation, natural process for debris removal in the cell, has been studied years. recent finding that degradation pathways can be utilized therapeutic purposes is paradigm shift drug discovery approach. Methods such as Proteolysis Targeting Chimera (PROTAC), lysosomal targeting chimera, hydrophobic tagging, AUtophagy TArgeting Chimera, AUTOphagy and several other variants these methods have made considerable impact on way design. Few selected examples testify huge wave change way. design based targeted protein powerful tool our arsenal. More molecules will invented uncover hidden secrets functioning provide enduring solutions unmet medical needs.