Precursor B- or T-lymphoblastic lymphoma presenting with cutaneous involvement: A series of 13 cases including 7 cases of cutaneous T-lymphoblastic lymphoma

• DOI: 10.1016/j.jaad.2013.10.020
• Publication Date: 2013-12-04T07:16:40Z
• Authors: Woo Jin Lee; Hye Rim Moon; Chong Hyun Won; Sung Eun Chang; Jee Ho Choi; Kee Chan Moon; Mi Woo Lee
• Keywords: Adult; Male; Adolescent; Biopsy, Needle; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Immunohistochemistry; Risk Assessment; Disease-Free Survival; Sampling Studies; Lymphoma, T-Cell, Cutaneous; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Child, Preschool; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Antineoplastic Combined Chemotherapy Protocols; Humans; Female; Neoplasm Invasiveness; Child; Neoplasm Staging; Retrospective Studies

Lymphoblastic lymphoma (LBL) is a rare neoplasm of precursor lymphocytes, and cutaneous involvement is present in less than 20% of cases.We sought to describe the clinical and histopathological features of cutaneous LBL.We retrospectively examined the clinical and histologic features of 13 patients with cutaneous LBL, 6 with B-LBL and 7 with T-LBL.Five of 6 patients with B-LBL had lesions in the head and neck area, whereas 4 of 7 patients with T-LBL developed skin lesions on sites other than the head and neck. Seven patients (1 case of B-LBL, and 6 of 7 cases of T-LBL) developed multiple skin lesions, and the T-LBL cases frequently developed multiple skin lesions in the head, neck, and throughout the torso. Complete remission was achieved in 9 patients (3 patients with T-LBL and all patients with B-LBL).This study used a retrospective design and included a small sample size.This study compared the clinical features of T-LBL and B-LBL, in particular the affected sites and number of skin lesions. Cutaneous T-LBL is likely to be accompanied by disseminated disease and has a relatively poor prognosis compared with B-LBL.