Lipoprotein(a) Induces Human Aortic Valve Interstitial Cell Calcification

• DOI: 10.1016/j.jacbts.2017.03.015
• Publication Date: 2017-08-28T18:16:55Z
• Authors: Bin Yu; Anouar Hafiane; George Thanassoulis; Leah Ott; Nial Filwood; Marta Cerruti; Ophélie Gourgas; Dominique Shum-Tim; Hamood Al Kindi; Benoit de Varennes; Alawi Alsheikh-Ali; Jacques Genest; Adel Schwertani
• Keywords: matrix Gla protein; Lipoprotein(a)

Lipoprotein(a), or Lp(a), significantly increased alkaline phosphatase activity, release of phosphate, calcium deposition, hydroxyapatite, cell apoptosis, matrix vesicle formation, and phosphorylation signal transduction proteins; expression chondro-osteogenic mediators; decreased SOX9 Gla protein (p < 0.001). Inhibition MAPK38 GSK3β reduced Lp(a)-induced calcification human aortic valve interstitial cells There was abundant presence Lp(a) E06 immunoreactivity in diseased valves. The present study demonstrates a causal effect for suggests that interfering with the Lp(a)pathway could provide novel therapeutic approach management this debilitating disease.