Differential Leaflet Remodeling of Bone Marrow Cell Pre-Seeded Versus Nonseeded Bioresorbable Transcatheter Pulmonary Valve Replacements

• DOI: 10.1016/j.jacbts.2019.09.008
• Publication Date: 2019-12-12T02:36:06Z
• Authors: Emanuela S. Fioretta; Valentina Lintas; Anna Mallone; Sarah E. Motta; Lisa von Boehmer; Petra E. Dijkman; Nikola Cesarovic; Etem Caliskan; Héctor Rodriguez ...; Miriam Lipiski; Mareike Sauer; Matilde Putti; Henk M. Janssen; Serge H. Söntjens; Anthal I.P.M. Smits; Carlijn V.C. Bouten; Maximilian Y. Emmert; Simon P. Hoerstrup
• Keywords: PRECLINICAL RESEARCH; 03 medical and health sciences; 0302 clinical medicine; endogenous tissue regeneration; RC666-701; in situ tissue engineering; Diseases of the circulatory (Cardiovascular) system; supramolecular polymer; cardiovascular regenerative medicine; tissue-engineered heart valve

JACC: Basic to Translational Science, 5 (1)<br/>This study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement in sheep. We also showed heterogeneous valve and leaflet remodeling, which affects PC-BU TEHV safety, challenging their potential for clinical translation. We suggest that bone marrow mononuclear cell pre-seeding should not be used in combination with PC-BU TEHVs. A better understanding of cell–scaffold interaction and in situ remodeling processes is needed to improve transcatheter valve design and polymer absorption rates for a safe and clinically relevant translation of this approach.<br/>ISSN:2452-302X<br/>