SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

• DOI: 10.1016/j.jacbts.2021.01.002
• Publication Date: 2021-02-26T21:42:29Z
• Authors: Adam L. Bailey; Oleksandr Dmytrenko; Lina Greenberg; Andrea L. Bredemeyer; Pan Ma; Jing Liu; Vinay Penna; Emma S. Winkler; Sanja Sviben; Erin Brooks; Ajith P. Nair; Kent A. Heck; Aniket S. Rali; Leo Simpson; Mehrdad Saririan; Dan Hobohm; W. Tom Stump; James A. Fitzpatrick; Xuping Xie; Xianwen Zhang; Pei-Yong Shi; J. Travis Hinson; Weng-Tein Gi; Constanze Schmidt; Florian Leuschner; Chieh-Yu Lin; Michael S. Diamond; Michael J. Greenberg; Kory J. Lavine
• Keywords: Pathogenesis; Viral Myocarditis; Coronavirus

There is ongoing debate as to whether cardiac complications of coronavirus disease-2019 (COVID-19) result from myocardial viral infection or are secondary systemic inflammation and/or thrombosis. We provide evidence that cardiomyocytes infected in patients with COVID-19 myocarditis and susceptible severe acute respiratory syndrome 2. establish an engineered heart tissue model pathology, define mechanisms pathogenesis, demonstrate cardiomyocyte 2 results contractile deficits, cytokine production, sarcomere disassembly, cell death. These findings implicate direct the pathogenesis pathology provides a system study this emerging disease.