Thrombospondin-1 Drives Cardiac Remodeling in Chronic Kidney Disease

• DOI: 10.1016/j.jacbts.2024.01.010
• Publication Date: 2024-03-27T19:36:43Z
• Authors: Sohel M. Julovi; Katie Trinh; Harry Robertson; Cuicui Xu; Nikita Minhas; Seethalakshmi Vis...; Ellis Patrick; John D. Horowitz; Daniel N. Meijles; Natasha M. Rogers
• Keywords: Thrombospondin 1; Ventricular remodeling; Cardiac Fibrosis; Ventricular hypertrophy

Patients with chronic kidney disease (CKD) face a high risk of cardiovascular disease. Previous studies reported that endogenous thrombospondin 1 (TSP1) involves right ventricular remodeling and dysfunction. Here we show murine model CKD increased myocardial TSP1 expression produced left hypertrophy, fibrosis, knockout mice were protected from these features. In vitro, indoxyl sulfate is driving deleterious changes in cardiomyocyte through the TSP1. patients CKD, aryl hydrocarbon receptor both differentially expressed myocardium. Our findings summon large clinical to confirm translational role CKD.