Deleterious Anti-Inflammatory Macrophage Recruitment in Early Post-Infarction Phase

• DOI: 10.1016/j.jacbts.2024.01.019
• Publication Date: 2024-04-24T18:56:55Z
• Authors: Alexandre Paccalet; Sally Badawi; Bruno Pillot; Lionel Augeul; Laura Mechtouff; Zeina Harhous; Yves Gouriou; Mélanie Paillard; Marine Breuilly; Camille Amaz; Yvonne Varillon; Simon Leboube; Camille Brun; Cyril Prieur; Gilles Rioufol; Nathan Mewton; Michel Ovize; Gabriel Bidaux; Thomas Bochaton; Claire Crola Da S...

Using a translational approach with an ST-segment myocardial infarction (STEMI) cohort and mouse model of infarction, we highlighted the role secreted IL-6 MCP-1 cytokines STAT3 pathway in heart macrophage recruitment activation. Cardiac myocytes secrete response to hypoxic stress, leading and/or polarization anti-inflammatory macrophages via pathway. In our preclinical neutralization or reduced infarct size. Together, data demonstrate that can be deleterious acute phase STEMI.