Endothelial Shear Stress Metrics Associate With Proinflammatory Pathways at the Culprit Site of Coronary Erosion

• DOI: 10.1016/j.jacbts.2024.07.008
• Publication Date: 2024-09-25T18:07:42Z
• Authors: Mona E. Ahmed; David M. Leistner; Diaa Hakim; Youssef Abdelwahed; Ahmet U. Coskun; Charles Maynard; Claudio Seppelt; Gregor Nelles; Denitsa Meteva; Nicholas V. Cefalo; Peter Libby; Ulf Landmesser; Peter H. Stone
• Keywords: Culprit; Proinflammatory cytokine

Low endothelial shear stress (ESS) and associated adverse biomechanical features stimulate inflammation, contribute to atherogenesis, predispose coronary plaque disruption. The mechanistic links between flow-related hemodynamics inflammatory mediators implicated in erosion, however, remain little explored. We investigated the relationship of high-risk ESS metrics culprit lesion proinflammatory/proatherogenic cells cytokines/chemokines erosion patients with acute syndromes. In eroded plaques, low ESS, high gradient, steepness topographical slope increased numbers local T subsets (CD4