Endothelial JCAD Worsens Acute Ischemic Stroke Outcomes by Enhancing Inflammation in Response to Ischemia/Reperfusion

• DOI: 10.1016/j.jacbts.2024.09.009
• Publication Date: 2024-11-27T19:07:46Z
• Authors: Stefano Ministrini; Yustina M. Puspit...; Georgia Beer; Lena Schwarz; Rebecca Niederberger; Simon Kraler; Florian A. Wenzl; Mira Katan; Marco Bacigaluppi; Aurora Semerano; Alexander Akhmedov; Susan Bengs; Fabrizio Montecucco; Thomas F. Lüscher; Giovanni G. Camici; Luca Liberale
• Keywords: Stroke; Endothelial Dysfunction

The role of junctional protein associated with coronary artery disease (JCAD) in acute ischemic stroke (AIS) has not been investigated yet. To investigate its potential as a therapeutic target, transient middle cerebral occlusion was induced JCAD knockout mice, improvement outcome and reduced blood-brain barrier permeability expression vascular cell adhesion molecule (VCAM)-1. plays deleterious ischemia/reperfusion damage associates higher 90-day mortality patients AIS. may thus represent novel prognostic biomarker for AIS, well target.