Airborne dust and high temperatures are risk factors for invasive bacterial disease

• DOI: 10.1016/j.jaci.2016.04.062
• Publication Date: 2016-07-16T19:15:22Z
• Authors: Jean-François Jusot; Daniel R. Neill; Elaine M. Waters; Mathieu Bangert; Marisol Collins; Laura Bricio Moreno; Katiellou G. Lawan; Mouhaiminou Mouss...; Emma Dearing; Dean B. Everett; Jean-Marc Collard; Aras Kadioglu
• Keywords: Inhalation exposure; Bacterial disease

<h3>Background</h3> The Sahel region of West Africa has the highest bacterial meningitis attack and case fatality rate in world. effect climatic factors on patterns invasive respiratory disease is not well documented. <h3>Objective</h3> We aimed to assess link between occurrence a Niger. <h3>Methods</h3> conducted daily surveillance monitoring over an 8-year period January 1, 2003, December 31, 2010, Niamey, Niger, determine risk for disease. investigated mechanistic effects these <i>Streptococcus pneumoniae</i> infection mice. <h3>Results</h3> High temperatures low visibility (resulting from high concentrations airborne dust) were identified as significant meningitis. Dust inhalation or exposure promoted progression stable asymptomatic pneumococcal nasopharyngeal carriage pneumonia significantly reduced phagocyte-mediated killing, increased release key toxin pneumolysin through autolysis. <h3>Conclusion</h3> Our findings show that can have substantial influence infectious patterns, altering density carriage, reducing phagocytic resulting inflammation tissue damage consequent invasiveness. Climatic should be used forecast epidemics, simple control measures reduce particulate might incidence regions world exposed dust.