Immunologic memory to SARS-CoV-2 in convalescent COVID-19 patients at 1 year postinfection

• DOI: 10.1016/j.jaci.2021.09.008
• Publication Date: 2021-09-15T06:13:36Z
• Authors: Hongyan Hou; Yandi Zhang; Guoxing Tang; Ying Luo; Wei Liu; Chang Cheng; Yuhuan Jiang; Zhigang Xiong; Shiji Wu; Ziyong Sun; Shabei Xu; Xionglin Fan; Feng Wang
• Keywords: TIGIT; Antibody titer; Coronavirus; Humoral immunity

Understanding the complexities of immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is key gain insights into durability protective immunity against reinfection.We sought evaluate SARS-CoV-2 in convalescent patients with longer follow-up time.SARS-CoV-2-specific humoral and cellular responses were assessed disease 2019 (COVID-19) at 1 year postinfection.A total 78 COVID-19 (26 moderate, 43 severe, 9 critical) recruited after recovery. The positive rates both anti-receptor-binding domain antinucleocapsid antibodies 100%, whereas we did not observe a statistical difference antibody levels among different severity groups. Accordingly, prevalence neutralizing (nAbs) reached 93.59% patients. Although nAb titers displayed an increasing trend increased severity, failed achieve significance. Notably, there was significant correlation between levels. Interestingly, SARS-CoV-2-specific T cells could be robustly maintained patients, their number positively correlated Amplified CD4+ mainly produced single cytokine, accompanying expression exhaustion markers including PD-1, Tim-3, TIGIT, CTLA-4, CD39, while proportion multifunctional low.Robust are postinfection. However, dysfunction supports notion that vaccination needed for preventing reinfection.