Mental health outcomes after SARS-CoV-2 vaccination in the United States: A national cross-sectional study

• DOI: 10.1016/j.jad.2021.10.134
• Publication Date: 2021-11-11T01:32:28Z
• Authors: Shanquan Chen; Athina R. Aruldass; Rudolf N. Cardinal
• Keywords: Cross-sectional study; 2019-20 coronavirus outbreak

Worsening of anxiety and depressive symptoms have been widely described during the COVID-19 pandemic. It can be hypothesized that vaccination could link to reduced and/or depression. However, date, no study has assessed this. This aims examine after in US adults, meanwhile test sociodemographic disparities these outcomes. Data from January 6-June 7 2021, cross-sectional Household Pulse Survey were analyzed. Using survey-weighted logistic regression, we relationships between SARS-CoV-2 symptoms, both on overall subgroups. We controlled for a variety potential socioeconomic demographic confounding factors. Of 453,167 participants studied, 52.2% had received vaccine, 26.5% 20.3% reported depression, respectively. Compared those not vaccinated, vaccinated 13% lower odds (adjusted ratio [AOR] = 0.85, 95%CI 0.83–0.90) 17% depression (AOR 0.83, 0.79–0.85). Disparities above associations identified age, marital status, education level, ethnic/race, income but gender. The causal inference was able investigated due design. Being associated with symptoms. While more middle-aged or affluent, likely show negative associations, contrary observed ethnic minorities educational attainment. More strategic demography-sensitive public health communications perhaps temper issues.