Stress-induced alterations in resting-state functional connectivity among adolescents with non-suicidal self-injury

• DOI: 10.1016/j.jad.2023.07.032
• Publication Date: 2023-07-10T15:32:47Z
• Authors: Alexandra Otto; Irina Jarvers; Stephanie Kandspe...; Corinna Reichl; Ayaka Ando; Julian Koenig; Michael Kaess; Romuald Brunner
• Keywords: Alertness

Non-suicidal self-injury (NSSI) is a major mental health problem among youth worldwide. Dysfunction in emotion regulation contributes to NSSI, but research on the underlying neurobiological mechanisms of NSSI limited. Adolescents with difficulties are vulnerable stress, making them susceptible maladaptive coping such as NSSI. This study examined functional neurocircuitry relevant and stress individuals compared healthy controls. case-control included 34 adolescents (15.91 years) 28 (16.0 unaffected Participants underwent magnetic resonance imaging scan before after completing laboratory stress-induction paradigm (the Montreal Imaging Stress Test). The effects induction were quantified by both physiological measures self-reports. showed distinctive alterations resting-state following induction, which differentiated from Results show reduction connectivity between frontoparietal regions angular gyrus within patient group controls, well an increase visual regions, insular cortex, planum polare, central opercular cortex. After conditions acute changes associated sensorimotor alertness, attention, effortful regulation. suicidal behavior, therefore results might be partly due suicidality. findings emphasize importance targeting therapeutic approaches enhance capacity, turn may contribute counteracting self-injurious behavior.