IC‐P‐110: Regional FDG metabolism and instrumental activities of daily living across the spectrum of Alzheimer's disease

• DOI: 10.1016/j.jalz.2013.05.107
• Publication Date: 2013-10-09T20:46:37Z
• Authors: Kamolika Roy; Lesley Pepin; Marlie Philiossaint; Natacha Lorius; Alex Becker; Joseph Locascio; Dorene Rentz; Reisa Sperling; Keith Johnson; Gad Marshall
• Keywords: 03 medical and health sciences; 0302 clinical medicine

Impairment in instrumental activities of daily living (IADL) begins as individuals with amnestic mild cognitive impairment (MCI) transition to Alzheimer's disease (AD) dementia. IADL AD dementia has been associated inferior parietal, temporal, and superior occipital hypometabolism using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET). The objective this study was investigate the relationship between regional FDG metabolism cross-sectionally longitudinally clinically normal (CN) elderly, MCI, subjects. Four hundred two subjects (104 CN, 203 95 at baseline) participating Disease Neuroimaging Initiative underwent clinical assessments every 6 12 months for up 3 years FDG-PET baseline. subjective informant-based Functional Activities Questionnaire (FAQ) used assess IADL. We first performed data reduction analyses reduce 35 regions that appeared best total FAQ score were significant after adjusting multiple tests. These entered into a general linear model backward elimination (p<0.05) assessing their cross-sectional relation baseline mixed random fixed coefficient longitudinal regression over time. Analyses included following covariates: diagnosis, demographics, Apolipoprotein E4 (APOE4) carrier status, memory executive function, behavioral factors. analysis showed middle frontal (p=0.003) orbitofrontal (p=0.009) significantly greater impairment, interaction diagnosis posterior cingulate (p<0.0001) parahippocampal (p=0.0008) steeper decline performance decreasedfor group relative MCI group, CN group. (p=0.0005) (p=0.004) rate increase results suggest medial parietal synaptic dysfunction relates functional time across spectrum independent APOE4 function performance,