Plasma β‐amyloid 40 levels are positively associated with mortality risks in the elderly

• DOI: 10.1016/j.jalz.2014.04.515
• Publication Date: 2014-07-09T02:32:11Z
• Authors: Audrey Gabelle; Susanna Schraen; Laure‐Anne Gutierrez; Cecile Pays; Olivier Rouaud; Luc Buée; Jacques Touchon; Catherine Helmer; Jean‐Charles Lambert; Claudine Berr
• Keywords: Male; Risk; 0301 basic medicine; Amyloid beta-Peptides; Kaplan-Meier Estimate; Peptide Fragments; 3. Good health; Random Allocation; 03 medical and health sciences; [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie; Case-Control Studies; Humans; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; Female; France; Prospective Studies; Cystatin C; Mortality; Aged; Follow-Up Studies; Proportional Hazards Models

Abstract Background We evaluated if plasma β‐amyloid (Aβ) levels were associated with mortality risks in a subsample of the French Three‐City (3C) prospective cohort study. Methods Analyses based on 1254 participants randomly selected from initial 3C stratified by center, sex, and age context nested case‐cohort study to investigate biological variables. Associations between Aβ assessed Cox regression model delayed entry including various potential confounding factors testing possible mediators. Results A relationship high 1‐40 concentrations risk (hazards ratio, 1.15; 95% confidence interval, 1.01–1.31, P = .03) was unveiled independently age, educational level, vascular factors, diet, physical activity, cognitive impairment, or frailty status. It only modified when we included cystatin C levels. Conclusions Further investigations are needed determine precisely pathophysiological roles before envisioning any future clinical applications.