P3‐316: High cholesterol diet during pregnancy attenuates amyloid pathology, cognitive deficit, and synaptic dysfunction in the offspring of 3xTg Alzheimer's disease mice

• DOI: 10.1016/j.jalz.2015.06.1690
• Publication Date: 2015-12-15T10:37:07Z
• Authors: Antonio Di Meco; Elisabetta Lauretti; Domenico Pratico
• Keywords: 03 medical and health sciences; 0302 clinical medicine

The identification of risk factors for sporadic late-onset Alzheimer's disease (AD) is important because it can provide mechanistic, diagnostic and therapeutic clues into this chronic neurodegenerative disorder. A family history AD increases the to develop disease, a maternal influences more than paternal one. While dietary lifestyle and, in particular, direct exposure high cholesterol saturated fat diet known modulate many aspect phenotype, no information available on impact that factor has unexposed offspring. To end, we administered fat/cholesterol triple transgenic (3xTg) dams ad libitum during entire pregnancy time. Offspring from regular chow treated 3xTg (controls) were compared with offspring fed later life their memory, learning ability brain pathology. Compared controls, diet-treated mothers displayed improvement memory abilities. same animals had significant reduction amyloidosis synaptic function. These effects associated lower mRNA protein BACE-1 expression levels. We conclude rich provides long-lasting protection against onset development AD-like phenotype by improving cognition amyloid better understanding different lifestyles could help us shed new insights influence pathophysiology life.