P3‐104: Associations between subjective memory complaints and hippocampal volume in preclinical early‐onset Alzheimer's disease

• DOI: 10.1016/j.jalz.2015.06.972
• Publication Date: 2015-12-15T10:36:07Z
• Authors: Yakeel T. Quiroz; Rebecca Amariglio; Daniel C. Aguirre...; Sandra Opoka; Brendan Pulsifer; Sehily Y. Jaimes; Gabriel Castrillon; Victoria Tirado; Claudia Munoz; Reisa A. Sperling; Francisco Lopera
• Keywords: Early-onset Alzheimer's disease; PSEN1; Association (psychology); Boston Naming Test

There is increasing evidence that subjective memory complaints (SMC) may be one of the earliest clinical signs preclinical Alzheimer's disease (AD) in late-onset AD. Understanding relevance SMC early-onset AD relatively underexplored. Our goal was to examine self-reported and informant-based young cognitively-intact individuals who carry E280A mutation presenilin-1 (PSEN1) gene age-matched noncarriers. Furthermore, we sought association between with hippocampal volume. Participants were 51 volunteers from a Colombian kindred autosomal dominant AD; 25 positive for AD-associated PSEN1 (mean age 34 +/- 7 years), whereas 26 noncarriers 37 6 years). All participants underwent comprehensive neuropsychological assessments, structural MRI scans. Participant-informant dyads asked complete 15-item questionnaire (Acosta-Baena, et al. 2011). We compared groups using t-test analyses calculated Cohen effect size (d). Pearson correlation coefficients (R) performed explore associations ratings Groups did not differ age, education, ratio men women, or performance on cognitive measures (e.g. memory, language, visuospatial executive functioning). no differences Self-reported higher carrier group non-carrier (d= 0.72, p-value= 0.01), there across ratings. In carriers alone, significantly correlated volume (R= -0.47, p-value=0.04). These findings suggest sign subtle changes familial disease. By contrast, more relevant diagnosis as AD-related limbic neurodegeneration progresses. Further research needed determine whether could useful identifying at high risk develop