Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease

• DOI: 10.1016/j.jalz.2016.06.005
• Publication Date: 2016-07-16T18:14:14Z
• Authors: Juan Domingo Gispert; Marc Suárez‐Calvet; Gemma C. Monté; Alan Tucholka; Carles Falcon; Santiago Rojas; Lorena Rami; Raquel Sánchez‐Valle; Albert Lladó; Gernot Kleinberger; Christian Haass; José Luis Molinuevo
• Keywords: Male; pathology [Cognitive Dysfunction]; diagnostic imaging [Cognitive Dysfunction]; tau Proteins; cerebrospinal fluid [Amyloid beta-Peptides]; pathology [Alzheimer Disease]; 03 medical and health sciences; 0302 clinical medicine; pathology [Gray Matter]; Alzheimer Disease; Humans; Cognitive Dysfunction; ddc:610; Gray Matter; Aged; Inflammation; Amyloid beta-Peptides; Middle Aged; Magnetic Resonance Imaging; 3. Good health; cerebrospinal fluid [Alzheimer Disease]; cerebrospinal fluid [Cognitive Dysfunction]; cerebrospinal fluid [Biomarkers]; cerebrospinal fluid [tau Proteins]; Female; diagnostic imaging [Alzheimer Disease]; Biomarkers

Abstract Introduction TREM2 is involved in the regulation of inflammatory response and phagocytosis. A soluble fragment (sTREM2) often found abnormally increased cerebrospinal fluid (CSF) Alzheimer's disease (AD). Methods One hundred fourteen participants (45 control, 19 preclinical, 27 mild cognitive impairment [MCI], 23 AD) underwent CSF sTREM2 determination magnetic resonance imaging (MRI). We studied association between sTREM2, gray matter volume, water motion diffusivity anisotropy across groups. Results In MCI patients, a positive correlation volume was bilateral inferior middle temporal cortices, precuneus, supramarginal, angular gyri, after controlling by age, sex, p‐tau. negative with mean detected overlapping regions, among others. Discussion early AD, augmented levels correspond cerebral MRI features typical brain swelling, supporting role for neuroinflammatory to neurodegeneration.