P3‐411: The Role of Dependence in Alzheimer's Disease Dementia: A Systematic Literature Review

• DOI: 10.1016/j.jalz.2016.06.2077
• Publication Date: 2016-10-17T07:22:56Z
• Authors: Caroline Marre; Kimberly Riggs; Jennifer Colby; Myrlene Sanon Aig...; Ann Hartry; Robin Tan; Amy Duhig; Trent McLaughlin
• Keywords: 03 medical and health sciences; 0302 clinical medicine

Evaluation of dependence has been suggested as a potential method for translating the effect changes in cognition, function, and behavior into more holistic description AD progression. This review evaluates existing literature regarding overall concept dependence, its measurement, relationship with longitudinal outcomes. A systematic peer-reviewed articles published between January 1995 October 2015 was performed using MEDLINE, EMBASE, Cochrane Central Library Controlled Trials. Randomized clinical trials observational studies evaluating ≥50 patients were included. Outcomes interest included over time, impact on behavior, quality life, associated economic burden dependence. 185 full-text references reviewed, 38 publications identified inclusion. Most focused data sets from prospective, including Predictors Study (n=11), Enhancing Care Alzheimer's Disease (ECAD) study (n=4), Co-Dependence (CoDep-AD) (n=2), Dependence England (DADE) ELN-AIP-901 (n=2). The most frequently used measurement Scale (DS) (n=33). Over range follow-up durations (1.5 to 6 years), significantly increased greater reported among severe disease. Among mild moderate (mean baseline DS = 5.3-5.4, based sum items {0,15}), scores 12 months, mean ranging 0.5 1 point. found be correlated variables life (QoL), caregiver burden. While association QoL varied by study, consistently shown increase patient also direct, informal care, total care costs. clarifies clinical, AD, corroborates previous understanding that may translate symptoms