[P2–323]: RELATIONSHIP BETWEEN COGNITIVE AND SLEEP‐WAKE VARIABLES IN ASYMPTOMATIC OFFSPRING OF PATIENTS WITH LATE‐ONSET ALZHEIMER's DISEASE

• DOI: 10.1016/j.jalz.2017.06.977
• Publication Date: 2017-10-20T08:30:41Z
• Authors: Carolina Abulafia; Barbara Duarte‐Ab...; Mirta F. Villareal; Soledad Ladrón‐de...; Celeste Garcia; Geraldine Sequeyra; Gustavo Sevlever; Leticia Fiorentini; Karl‐Jürgen Bär; Deborah R. Gustafson; Daniel E. Vigo; Salvador Martin G...
• Keywords: 03 medical and health sciences; 0302 clinical medicine

Early neuropathological changes characteristic of late-onset Alzheimer's disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep-wake rhythm. Indeed, sleep pattern is an emerging biomarker a potential pathophysiological mechanism in LOAD. We hypothesized cognitively asymptomatic, middle-aged offspring patients with LOAD would display series circadian rhythm abnormalities prior to the onset objective cognitive alterations. tested 31 (O-LOAD) 19 healthy individuals without family history AD (CS) basic tests function, as well actigraphy measures rhythm, cardiac autonomic bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits verbal episodic memory language compared CS, even though all participants had results within clinically normal range. showed phase-delayed body Cognitive performance was associated variables; specifically indicators greater sympathetic activity at night were related poorer cognition. The present add burgeoning evidence on early neurobiological signature LOAD, extending findings sample asymptomatic at-risk individuals.